DeepMind’s latest AI tool makes sense of changes in the human genome

DeepMind 的最新 AI 工具可以理解人类基因组的变化

关键词：

来源：

Science

来源地址：

https://www.science.org/content/article/deepmind-s-latest-ai-tool-makes-sense-changes-human-genome

资源所属：

马铃薯基因组设计育种

类型：

前沿资讯

语种：

英语

原文发布日期：

2025-06-25

摘要：

AlphaGenome,  is expected to make it easier for researchers to pinpoint the causes of diseases by more accurately tracking the consequences of genetic mutations, and help synthetic biologists design new genes from scratch. DeepMind officials say they are still working out how they will make the tool commercially available. But academic researchers can use it for free.AlphaGenome unites many of these analyses and others into a single package. It relies on massive molecular biology databases produced over decades by publicly funded consortia. These include the results of experiments tracking how certain mutations in human and mouse cells affect properties such as the production of RNA, which translates the genome’s blueprints into proteins, and levels of transcription factors, proteins that can turn genes on and off. By training on those data sets, AlphaGenome has learned to decipher DNA, identifying both genes and the nongene sequences that orchestrate gene activity, along with the genetic variants most likely to produce consequential changes.