A generative model for complete mRNA sequences that deliver custom therapeutic payloads

mDD-0：用于生成稳定 mRNA 序列的离散扩散模型

关键词：

来源：

ginkgo公司

来源地址：

https://www.ginkgo.bio/resources/white-papers/mrna-discrete-diffusion

资源所属：

马铃薯基因组设计育种

类型：

前沿资讯

语种：

英语

原文发布日期：

2025-02-13

摘要：

"Recent advances in AI have enabled remarkable progress in the design and optimization of messenger RNA (mRNA) for RNA vaccines and therapeutics. While recent work on mRNA design has largely focused on designing individual components of the mRNA sequence, designing end-to-end mRNA sequences presents a unique challenge. Specifically, designing functional mRNA requires joint optimization of the coding sequence (CDS) for a protein of interest in addition to the 3’ and 5’ untranslated regions (UTRs).Recently, diffusion models have emerged as a powerful generative framework for protein design and sequence generation, for example, Ginkgo's recently released antibody discrete diffusion model. Building on these advances, we introduce mRNA discrete diffusion (mDD-0), a discrete diffusion model for the generation of mRNA sequences."