The present invention relates to antibody-drug conjugates, wherein the antibody specifically binds to TfR, the transferrin receptor, and wherein the drug is preferably chosen among a cytotoxic drug. Such antibody-drug conjugates are useful in particular in treating proliferative diseases including cancers, such as lymphoma or leukaemia.本發明關於一種抗體-藥物綴合物,其中所述抗體特異性鍵結至TfR、轉鐵蛋白受體,且其中所述藥物較佳選自細胞毒性藥物。所述抗體-藥物綴合物特別可用於治療包括癌症的增殖性疾病,諸如淋巴瘤或白血病。