JAKOBOVITS, AYA,ETESSAMI, SOUDABEH,CHALLITA-EID, PIA M.,PEREZ-VILLAR, JUAN J.,MORRISON, KAREN J.,JIA, XIAO-CHI,FARIS, MARY,GUDAS, JEAN,RAITANO, ARTHUR B.
申请号：
PL04750565
公开号：
PL1742966T3
申请日:
2004.04.22
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response； antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
