VAJDY, MICHAEL,POLO, JOHN,DUBENSKY, THOMAS JR.,O'HAGAN, DEREK
申请号：
CA2434546
公开号：
CA2434546C
申请日:
2002.01.14
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
A replication-defective alphavirus replicon particle containing an alphavirusvectorconstruct comprising a heterologous polynucleotide encoding at least one firstantigen ormodified form thereof, said first antigen or modified form thereof beingcapable ofstimulating an immune response in a subject when administered intranasally,wherein saidreplication-defective alphavirus replicon particle is a chimeric alphavirusparticlecontaining a Venezuelan Equine Encephalitis (VEE) virus vector constructpackaged withSindbis (SIN) virus envelope glycoproteins, for use in treating a mammaliansubject bygenerating an immune response in the subject by intranasal administration. Theat leastone first antigen may be an antigen from a pathogen and induces an immuneresponse tothe pathogen. Additional antigens or immunostimulatory factors may also beencoded bythe chimeric replicon particle, or co-administered as a polypeptide.
