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POLYCYCLIC COMPOUND ACTING AS IDO INHIBITOR AND/OR IDO-HDAC DUAL INHIBITOR
专利权人:
Hangzhou Innogate Pharma Co.; Ltd.
发明人:
Hancheng ZHANG,Xiangyang YE
申请号:
US16649455
公开号:
US20200276180A1
申请日:
2018.09.20
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Compounds as IDO inhibitors and/or dual inhibitors of IDO-HDAC are described. Specifically, the compounds represented by the following formula (I) are described, wherein each group is defined as described in the specification. The compounds have IDO inhibitory activity or IDO-HDAC dual inhibitory activity and can be used for preventing or treating diseases associated with IDO and/or IDO-HDAC activity or expression levels. At the same time, the compounds of the present invention can be combined with an anti-tumor antibody such as PD-1 and PD-L1, and such a combination can greatly increase the anti-tumor response rate of the antibody and broaden the types of tumors to be treated.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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