Bakker, Talitha,Stumpp, Michael T.,Binz, Hans Kaspar,Phillips, Douglas,Dolado, Ignacio,Forrer, Patrik,Merz, Frieder W.,Sonderegger, Ivo,Steiner, Daniel,Gulotti-Georgieva, Maya,Abram Saliba, Johan
申请号：
AU2016240220
公开号：
AU2016240220A1
申请日:
2016.04.01
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for serum albumin, as well as recombinant binding proteins comprising at least one designed ankyrin repeat domain with binding specificity for hepatocyte growth factor (HGF), at least one designed ankyrin repeat domain with binding specificity for vascular endothelial growth factor (VEGF-A), and at least two designed ankyrin repeat domain with binding specificity for serum albumin are described, as well as nucleic acids encoding such designed ankyrin repeat domains and recombinant binding proteins, pharmaceutical compositions comprising such designed ankyrin repeat domains, recombinant binding proteins or nucleic acids and the use of such designed ankyrin repeat domains, recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.
