Systems and methods are presented that allow for selection of tumor neoepitopes that are filtered for various criteria. In particularly contemplated aspects, filtering includes a step in which the mutation leading to the neoepitope is ascertained as being located in a cancer driver gene.本發明提供允許選擇根據各種標準過濾之腫瘤新抗原決定基的系統及方法。在特定預期態樣中,該過濾包括查明產生該新抗原決定基之突變位於癌症驅動子基因中的步驟。