The present disclosure provides a use of an extract of Victoria cruziana for inducing expression of keratin gene and hyaluronan synthase 2 gene, and enhancing the moisture-retaining capacity of the skin.本發明提供一種魯茲王蓮的萃取物用於提升角蛋白基因及透明質酸合成酶2基因的表現量,及提升皮膚的保濕能力的用途。