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COMBINATIONS OF A PHOTOSENSITIZER WITH A HYDROGEN SULFIDE DONOR, THIOREDOXIN INHIBITOR OR NITROXIDE FOR USE IN PHOTODYNAMIC THERAPY
专利权人:
UNIVERSITY OF EXETER
发明人:
Mark Elliott WOOD,Paul Graham WINYARD,Daniel Colin Jeremy FERGUSON,Matthew WHITEMAN,Alison CURNOW,Alexis PERRY
申请号:
US15890576
公开号:
US20180161430A1
申请日:
2018.02.07
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention relates to a combination comprising(i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and(ii) a photosensitizer or photosensitizer precursor;for use in photodynamic therapy.
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