The present invention relates to the association of active principles, i.e. of a xanthine oxidase inhibitor with a biguanide derivative, preferably metformin, pharmaceutical compositions comprising said active principles, for use in a human or veterinary therapeutic treatment, and methods for the preparation thereof.本發明係關於活性成分之締合,亦即黃嘌呤氧化酶抑制劑與雙胍衍生物、較佳甲福明之締合;包含該等活性成分之醫藥組成物,其係用於人類或獸醫學治療性處理;及其製備方法。