The present invention relates to an insert for the infusion of drugs. The insert is suitable for connection to a vial and preferably to a circuit or an infusion line. Moreover the insert comprises a main body, a resilient element and a piercing spike. The piercing spike has an axis X and defines a first channel and a second channel and is movable relative to the main body along the axis X between a first closed position A and a second open position B. Moreover the resilient element presses against the piercing spike so as to keep it in the first closed position A when no external forces are applied.