The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof: In this formula, R 1 is (and wherein optional substituents include one or more substituents each independently selected from C 1-6 alkoxy), optionally substituted alkyl； An optionally substituted carbocycle reel (where optional substituents include C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy and one or more substituents each independently selected from halo do)； Or -alkylaryl； R 2 is H； Or alkyl； R 3 is H； Or alkyl； U, V and W is - (CH 2) -, or represent； Or U and V together represent -CH = CH-, W represents C = O； Y is aryl； Heteroaryl； An optionally substituted carbocycle reel (where optional substituents include C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy and one or more substituents each independently selected from halo do)； Or optionally substituted heterocyclyl (wherein optional substituent is C 1-6 alkyl, C 1-6alkoxy, -C (O) OC 1 - 6 alkyl, -C (O) C 1-6 alkyl, and -C ( O) NHC <； / RTI >；<； RTI ID = 0.0 >； 1-6 <； / RTI >；alkyl； Z is aryl； Heteroaryl； An optionally substituted carbocycle reel (where optional substituents include C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 haloalkoxy and one or more substituents each independently selected from halo do)； Or optionally substituted heterocyclyl (wherein optional substituent is C 1-6 alkyl, C 1-6alkoxy, -C (O) OC 1 - 6 alkyl, -C (O) C 1-6 alkyl, and -C ( O) NHC <； / RTI >；<； RTI ID = 0.0 >； 1-6 <； / RTI >； alkyl.본 발명은 모든 호변 이성체 및 입체이성체를 포함한 화학식 (I)의 화합물, 또는 그의 약학적으로 허용가능한 염, 용매화물 또는 다형체에 관한 것이다:상기 식에서,R1은 임의로 치환된 알킬 (여기서 임의적인 치환체는 C1-6알콕시로부터 각각 독립적으로 선택되는 하나 이상의 치환체를 포함한다)； 임의로 치환된 카보사이클릴 (여기서 임의적인 치환체는 C1-6알킬, C1-6알콕시, C1-6할로알킬, C1-6할로알콕시 및 할로로부터 각각 독립적으로 선택되는 하나 이상의 치환체를 포함한다)； 또는 -알킬아릴을 나타내고；R2는 H； 또는 알킬을 나타내고；R3은 H； 또는 알킬을 나타내고；U, V 및 W는 -(CH2)-를 나타내거나； 또는
