Provided herein are improved, commercially viable and industrially advantageous processes for the preparation of agomelatine, in high yield and purity, using novel intermediates. The process includes: a) reacting N-[2-(7-hydroxy-3,4-dihydro-1-naphthalenyl)ethyl] acetamide with a suitable activating agent b) subjecting the acylated compound to aromatization by reacting with a suitable aromatizing agent c) deprotecting the aromatized compound with a suitable deprotecting agent to produce the N-[2-(7-hydroxy-1-naphthalenyl)ethyl] acetamide d) reacting the deprotected compound with a methylating agent to produce agomeltaine.Linvention concerne des procédés améliorés, commercialement viables et industriellement avantageux, de préparation de lagomélatine dans un rendement élevé et avec une grande pureté, en ayant recours à de nouveaux intermédiaires.
