GREMLIN-1結晶結構及抑制抗體农业专利-农业学术服务平台

发明人:: DAVIES, GARETH,戴维斯　盖瑞斯,戴維斯　蓋瑞斯,DEDI, NEESHA,达迪　妮莎,達迪　妮莎,MCMILLAN, DAVID JAMES,麦克米兰　大卫　詹姆士,麥克米蘭　大衛　詹姆士,TWOMEY, BREDA,特梅　布雷达,特梅　布雷達,WRIGHT, MICHAEL JOHN,莱特　麦克　约翰,萊特　麥克　約翰,戴维斯盖瑞斯,戴維斯蓋瑞斯,达迪妮莎,達迪妮莎,麦克米兰大卫詹姆士,麥克米蘭大衛詹姆士,特梅布雷达,特梅布雷達,莱特麦克约翰,萊特麥克約翰

摘要：: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.本發明係關於人類Gremlin-1蛋白及與抑制抗體複合之人類Gremlin-1蛋白之結晶。本發明亦關於人類Gremlin-1 (獨自，或與抗體複合)之結構及此等結構在篩檢調節Gremlin-1活性之藥劑中的用途。本發明另外提供結合Gremlin-1上之異位抑制位點之抗體，以及此類抗體之醫藥組合物及醫學用途及藉由篩檢方法鑑別之藥劑。