Shuai Shi,Valentyn Antochshuk,Joseph Rizzo,Niels C. Kaarsholm
申请号：
US15966585
公开号：
US20180318426A1
申请日:
2018.04.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed is a pharmaceutical formulation comprising an insulin or insulin analog molecule covalently attached to at least one branched linker having a first arm and second arm, wherein the first arm is linked to a first ligand that includes a first saccharide and the second arm is linked to a second ligand that includes a second saccharide and wherein the first saccharide is fucose. The formulation is suitable for subcutaneous administration and provides a basal pharmacodynamic profile for the insulin oligosaccharide conjugate.
