Gabriela Hernandez-Hoyos,Elaine T. Sewell,Catherine J. McMahan,David Bienvenue,John W. Blankenship,Danielle Mitchell,Peter Pavlik
申请号：
US16335561
公开号：
US20200165346A1
申请日:
2017.09.21
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.
