RENJI HOSPITAL; SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE
发明人:
Houwen LIN,Fan YANG
申请号：
US16477748
公开号：
US20190350926A1
申请日:
2017.07.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A benzodiazepine alkaloid compound and a pharmaceutically acceptable salt thereof, the structure of the compound being shown in general formula (I).in the formula (I), R1, R2 and R3 independently are hydrogen, C1-4 alkyl or C1-4 alkanoyl； one from among R4 and R5 is a benzene ring or a substituted benzene ring, while the other is hydrogen, a benzene ring or a substituted benzene ring, wherein a substituent group on the substituted benzene ring is hydroxyl, cyano, amino, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylamine, C1-4 alkanoyl or C1-4 alkoxyacyl. A method for synthesizing the compound and a use in the preparation of anti-tumor drugs. The compound shown in formula (I) may be used for preparing anti-tumor, especially anti-lung cancer, drugs as well as anti-fungal drugs.
