David Campbell,Ramesh Bhatt,William J. Dower,Steven E. Cwirla,Blake M. Williams
申请号：
US15988944
公开号：
US20180339043A1
申请日:
2018.05.24
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are modified antibodies, pharmaceutical compositions thereof, as well as nucleic acids, and methods for making and discovering the same. The modified antibodies described herein are modified with a peptide. The peptide binds at or near the antigen binding site of the antibody at physiological pH, thus reducing binding affinity of the antibody for a target antigen. At acidic pH, the binding interaction of the peptide at or near the antigen binding site is disrupted, thus enabling binding with a target antigen.
