Such as the present invention is N, N- dimethyl yimido dicarboxylic reubon as already on nicotine salts, their preparation and pharmaceutical compositions comprising them Dick diamide, and more particularly, solubility, stability, non-hygroscopicity, the tablet formulation as processability the physical and chemical properties as well as have been improved, low toxicity, N, N- dimethyl yimido dicarboxylic reubon already Dick diamide about chemical properties of diabetes and diabetes, obesity, hyperlipidemia, fatty liver disease, coronary artery disease, osteoporosis, exhibiting essentially, polycystic ovarian syndrome, including diabetes treatment, root key causative agent of mild complications, prevention and treatment by the lipid-lowering effects and p53 gene lacking cancers, muscular pain, muscle cytotoxicity of diabetes parties complication of those with so-called metabolic syndrome appears as a complex and will further increase as a therapeutic agent for prevention and rhabdomyolysis that can astute available N, N- dimethyl-dicarboxylic reubon yimido the therapeutic effect of nicotine on the melting already salts, and its method of manufacturing the pharmaceutical composition of Dick diamide.Metformin, metformin, nicotinic acid, nicotinic acid salt is metformin, N, N- dimethyl yimido dicarboxylic reubon already Dick diamide, nicotine salts, crystalline acid addition salts, diabetes, metabolic syndrome본 발명은 N,N-디메틸 이미도디카르본이미딕 디아미드의 니코틴산염, 그의 제조방법 및 그를 포함하는 약제학적 조성물에 관한 것으로서, 더욱 상세하게는 용해도, 안정성, 비흡습성, 정제 제형으로서의 가공성 등의 물리화학적 성질이 개선되었을 뿐 아니라, 독성이 낮고, N,N-디메틸 이미도디카르본이미딕 디아미드가 본질적으로 발휘하는 약화학적 특성인 당뇨 및 당뇨병, 비만증, 고지혈증, 지방간, 관상동맥질환, 골다공증, 다낭성 난소증후군 등이 복합적으로 나타나는 이른바 대사성 증후군을 지닌 자들의 당뇨병 치료, 당뇨병자의 합병증의 근본 핵심 원인 물질인 중성 지질 저하 작용에 의한 합병증 예방 및 치료 그리고 p53 유전자가 결여된 암, 근육통, 근육세포 독성 및 횡문근 융해의 예방 및 치료 효과를 더욱 증가시켜줄 수 있는 치료제로서 유효한 N,N-디메틸 이미도디카르본이미딕 디아미드의 니코틴산염, 그의 제조방법과 그의 약제학적 조성물에 관한 것이다.
