Mario Otto,Dana C. Baiu,Bryan P. Bednarz,Jamey Paul Weichert
申请号：
US15647557
公开号：
US20180015113A1
申请日:
2017.07.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula:or salts thereof, wherein n is an integer from 12 to 24； and R2 is —N+(CH3)3. The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, R1 includes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, R1 includes a detection moiety, such as a fluorophore or a radioactive iodine isotope.
