#$%^&*AU2020101352A420200820.pdf#####ABSTRACT The invention discloses a probiotic and its application in secondary osteoporosis, belonging to the technical field of microorganisms. The invention discloses a Lactobacillus plantarum HFY15, characterized in that Lactobacillus plantarum HFY15 belongs to the genus of Lactic acid bacteria (LAB) and has been deposited in China General Microbiological Culture Collection Center, CGMCC with the preservation date of Oct. 29, 2018 and the preservation number is CGMCC No. 16648.This invention separates and identifies Lactobacillus plantarum HFY15 from natural yak yogurt； This invention used retinoic acid to establish a rat secondary osteoporosis (OP) model, and studied the preventive effect of HFY15 on OP. The results shows that the supplement of HFY15 increased the expression of osteogenic marker genes, inhibited the expression of osteoclast genes and stimulated bone formation. The research results provide a new and effective strategy for prevention and treatment of OP.
