SHUTE, Janis,CARROLL, Mary Patricia,CONWAY, Joy,HOCKEY, Peter
申请号：
ES03702776
公开号：
ES2565028T3
申请日:
2003.02.14
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A glucosaminoglycan selected from chondroitin A to E sulfates, heparin, heparin sulfate, heparan, heparan sulfate and keratan sulfate or a physiologically acceptable salt of said glucosaminoglycan for use in a method for treating a mammalian subject with a disorder or respiratory disease comprising increased levels and / or viscosity of mucus or other pulmonary secretions, where the disease or disorder is selected from chronic airflow limitation (CAL), pneumonia, sinusitis, nasal congestion, cystic fibrosis, asthma, bronchitis, tracheobronchitis , bronchiectasis, tuberculosis, fungal infection, viral infection or a respiratory tract infection, in which: - the subject is being treated with a therapeutic agent； - the glucosaminoglycan or salt and the therapeutic agent are administered by inhalation, intranasally and / or by instillation； - the agent has to be supplied to the respiratory tract； - said glycosaminoglycan or salt thereof has an average molecular weight of 12 to 18 kd； - the mucus or other pulmonary secretions contain extracellular genomic DNA that is compromising lung function； and - glucosaminoglycan increases the supply of the therapeutic agent.Un glucosaminoglucano seleccionado entre sulfatos de condroitina A a E, heparina, sulfato de heparina, heparán, sulfato de heparán y sulfato de queratán o una sal fisiológicamente aceptable de dicho glucosaminoglucano para su uso en un método para tratar a un sujeto mamífero con un trastorno o enfermedad respiratoria que comprende niveles y/o viscosidad aumentada de mucosidad u otras secreciones pulmonares, donde la enfermedad o trastorno se selecciona entre limitación crónica del flujo de aire (CAL), neumonía, sinusitis, congestión nasal, fibrosis quística, asma, bronquitis, traqueobronquitis, bronquiectasia, tuberculosis, infección fúngica, infección vírica o una infección del tracto respiratorio, en el que: - el sujeto se está tratando con un agente terapéutico； - el glucosaminoglucano o sal y el agente terapé
