SMITH, Jennifer, Joy,DANZIGER, Samuel, Anthony,AITCHISON, John, David,MILLER, Leslie, Rae
申请号：
EP20140847441
公开号：
EP3049532(A4)
申请日:
2014.09.25
申请国别(地区):
欧洲专利局
年份:
2017
代理人:
摘要：
Methods to detect amyotrophic lateral sclerosis (ALS) or presymptomatic Alzheimer's disease (PSAD) using an indicator cell assay platform (iCAP) in a test subject are described. Specifically, the disclosure provides a method comprising contacting a biological fluid of said test subject with indicator cells and assessing said indicator cells for the level of expression of an exon of CKIgamma2 that encodes the C-terminal palmitoylated region of said CKIgamma2, to determine the probability that a test subject is afflicted with amyotrophic lateral sclerosis (ALS). Further disclosed are methods of using indicator cells that are pan neuronal populations of glutamatergic (and/or GABAergic) neurons to determine the probability of the presence of presymptomatic or symptomatic Alzheimer's disease (PSAD) in a test subject.
