NEUMANN, CHRISTOPHER SCOTT,OLIVAS, KATHLEEN,LYON, ROBERT,WANG, KUNG-PERN
申请号：
CA3060206
公开号：
CA3060206A1
申请日:
2018.04.27
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.
