THE REPLICATION OR MITIGATION OF LOW FREQUENCY VIBRATION AND OTHER PHYSICAL FACTORS TO ENHANCE THE EFFECT OF THROMBOLYSIS ON PATIENTS WITH ISCHEMIC STROKE
Enrique C. Leira,Thomas Schnell,Salam F. Rahmatalla,Andrew A. Pieper,Anil Chauhan
申请号：
US16783003
公开号：
US20200316289A1
申请日:
2020.02.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The disclosed apparatus, systems and methods relate to devices, systems and methods for improving thrombolysis via synergetic application of thrombolytics with physical factors, such as in acute ischemic stroke patients. Vibration in the low (0.5-120 Hz) frequency range is synergistic with tissue plasminogen activators (rtPA), significantly improving the effectiveness of thrombolysis without impairing blood brain barrier permeability. Administration of low frequency vibration combined with rtPA improve acute ischemic stroke outcomes.
