Mihir Mandal,Timothy A. Blizzard,Helen Chen,Harry Chobanian,Yan Guo,Barbara Pio,Zhicai Wu,Tesfaye Biftu,William J. Greenlee,Johnny Zhaoning Zhu
申请号：
US14383176
公开号：
US20150025046A1
申请日:
2013.02.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: X is —O—, —N(R), —C(R8)(R9) or —C(O)—； and Y is —O—, —N(R), —C(R8)(R9) or —C(O)— and the remaining variables are described herein. The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ACS, secondary prevention of myocardial infarction or stroke, or PAD.
