PREPARATION OF N-MONOFLUOROALKYL TROPANES

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专利权人:

Jarle Andre Haugan;Gunnar Keilen;Lorenzo Williams

发明人:

Lorenzo Williams,Gunnar Keilen,Jarle Andre Haugan

申请号：

US13514074

公开号：

US20120244072A1

申请日:

2010.12.15

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention relates to an improved synthesis of N-monofluoroalkyl tropanes using fluoroalkyl iodides or fluoroalkyl sulfonate esters. The invention also provides the use of such method to prepare the non-radioactive tropane intermediate FP-CIT, and its subsequent conversion to the 123I-labelled radiopharmaceutical DaTSCAN™ (123I-ioflupane). Also provided is the use of fluoroalkyl iodides or fluoroalkyl sulfonate esters in the alkylation method of the invention.

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