BARNETT, Stuart, Anthony,JONES, Craig, Warren,KHOSHDEL, Ezat,MERRINGTON, James,THOMPSON, Katherine, Mary
申请号：
EPEP2016/081814
公开号：
WO2017/108725A1
申请日:
2016.12.19
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
A method of delivering an active agent to skin, preferably axilla, comprising the steps of: a) applying to skin an antiperspirant composition comprising an antiperspirant (AP) active selected from astringent active salts comprising aluminium, zirconium and mixed aluminium /zirconium salts and at least 0.1 wt% of core shell microcapsules whereby the microcapsules come into contact with the skin each microcapsule having an inner shell formed of a first synthetic polymer and containing the active agent and the inner shell capable of allowing at least a portion of the active agent to pass from inside the inner shell to outside the inner shell to enable it to come into contact with the skin, the inner shell being coated with a coating of insoluble polyamide with a solubility in water of less than 1 g/L at 25°C, the polyamide formed by the reaction of: (i) at least one low molecular weight dicarboxylic acid having from 3 to 12 carbon atoms, or ester thereof； (ii) at least one poly(alkylene glycol) polyamine having the formula (I) H2N-(-C(R)H-CH2-O-)x-C(R)H-CH2-NH2 (I) where x ranges from about 2 to 5, R is an alkyl of one to four carbon atoms； (iii) optionally, at least one high molecular weight dicarboxylic acid (dimer) having from 20 to 40 carbon atoms, or ester thereof； and wherein the coating further comprises a crosslinker to improve hardness and further reduce solubility, such that, while the coating is present the release of the active agent onto the skin is retarded； b) sweating to produce sweat that comes into contact with at least part of the polyamide coating and the antiperspirant active； c) degrading the polyamide coating by the action of protease enzymes present in the sweat thereby to cause delayed release of the active agent onto the skin after the microcapsule first comes into contact with sweat.La présente invention concerne une méthode d'administration d'un agent actif sur la peau, de préférence au niveau des aisselles, comprenant les étapes consistant
