Sanjay AWASTHI,Sushma YADAV,Ismail AL ABDULLAH,Fouad KANDEEL,Brian MCFADDEN,Indu NAIR,Sharad S. SINGHAL
申请号：
US14659568
公开号：
US20160151423A1
申请日:
2015.03.16
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides novel methods for increasing β-cell viability in islets by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof； or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to the islets. The disclosure also provides novel methods for treating a disease or condition in a subject, such as type 1 diabetes mellitus, by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof； or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to islets and transplanting the islets into the subject to treat the disease or condition. Kits and compositions including RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof； or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, are also provided to increase β-cell viability.
