The Johns Hopkins University;Kennedy Krieger Institute, Inc.
发明人:
Kannan RANGARAMANUJAM,Sujatha KANNAN,Elizabeth NANCE,Mary E. BLUE,Michael V. JOHNSTON,William BAUMGARTNER,Fan ZHANG,Mary Ann WILSON,Barbara SLUSHER
申请号：
US15502744
公开号：
US20170232120A1
申请日:
2015.08.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A dendrimer formation, such as a PAMAM dendrimer or a multiarm PEG polymeric formulation has been developed for systemic administration to the brain or central nervous system. In the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine) (PAMAM) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for treatment of one or more symptoms of neurodegenerative, neurodevelopmental or neurological disorders such as Rett syndrome or autism spectrum disorders, D6 generation dendrimers provide significantly enhanced uptake into areas of brain Injury, providing a means for diagnosis as well, as drug delivery.
