The invention relates to a pharmaceutical preparation of the cream type having antimicrobial, antifungal, anti-inflammatory and wound healing effects and to a process for preparing the same. According to the invention, the preparation comprises 0.01...0.1% metal complexes of chlorhexidine with Cu(II), Zn(II), Ag(I) in association with usual excipients. The process claimed by the invention consists in hot emulsifying the weighed starting materials, followed by trituration until the product is cooled and conditioning of the final product.