KOUL ANIL,YSEBAERT NINA,GOEVAERTS, NELE ISA E.,ROYMANS DIRK ANDRÉ E.
申请号：
CL2019001454
公开号：
CL2019001454A1
申请日:
2019.05.29
申请国别(地区):
CL
年份:
2019
代理人:
摘要：
<；p>； The present invention relates to the combination of the compound to the inhibitor of vsr, that is, 3 - ({5- cioro-lquot； [3- (methylsuifoniexcl； i) propyl] -l / findoi- 2-yl} methyl) -l- (2,2,2-trifluoroethyl) -l, 3-dihydroldquo； 2 / y-imidazo [4,5- c] pyridin-2-one, and one or more compounds b vsr inhibitors selected from ribavirin, gs-5806, mdt-637, bta-9881, bms-433771, ym-543403, a-60444, tmc-353121, rfi-641, cl-387626, mbx-300, az- 27, medi8897, cr9501, paliacute； viacute； zumab, 3 - ({5-chloro-l- [3ldquo； (methylsulfonyl) propii] -l / fbenzimidazol-2-yl} methyl) -l-cyclopropyl-l, 3- dihydro-2a # 39； -imidazo [4,5-c] pyridin-2-one,3 - [[7-Chloro-3- (2- ethylsulfonylethyl) imidazo [l, 2-5] pyriacute； din-2-yl] methyl] -l-cyclopropylimidazo [4,5-c] pyridin-2-one, methylphenyl) -6- (4- {5-methyl-2- (7-oxa-2-aza5piro [3.5] nonan-2-yl) nicotinamide) benzoyl) -5,6-dihydro-4 / a benzo [iquest； 7] thieno [2,3-o] azepino-2-carboxamide, and 4ldquo； amiacute； no-8- [3 - [[2- {3,4-dimethoxyphenyl} ethyl] amino] propyl] -6, 6- dimethyl-2- (4-methyl-3-nitrophenyl) -3 / fimidazo [4,5- / 7] isoquinoline-7,9 (6a # 39； 8 / ^ - dione to treat or improve infection by e The invention also refers to the combined product of the compound a and one or more compounds b,a pharmaceutical product comprising the compound a and one or more compounds b, the use of the combination of the compound a and one or more compounds b (or the pharmaceutical product comprising the compound a and one or more) ； s compounds b) for the treatment of infection by the VSR, and a method to treat or improve infection by the VSR in a subject in need that comprises administering the combination of compound a and one or maacute； s compounds b in an effective amount to said subject. <；/p>；<；p>；La presente invenció；n se refiere a la combinació；n del compuesto a inhibidor del vsr, es decir, 3-({5- cioro-l"[3-(metilsuifon¡；i)propil]-l/findoi-2-il}metil)-l-(2,2,2-trifluoroetil)-l,3-di
