MUTTER, Manfred,BELLOCQ, Nathalie,BIASSE, Daniel,RAZANAME, Alain,MARX, Léo,CHARDONNENS, Christophe,GARROUSTE, Patrick
申请号：
AU2018368520
公开号：
AU2018368520A1
申请日:
2018.11.14
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention relates to ligand-drug-conjugates for the treatment of disease. In particular, the present invention relates to ligand-drug-conjugates comprising a linker system, which is selectively recognized and cleaved by the exopeptidase (i.e. carboxydipeptidase) activity of Cathepsin B, resulting in improved intracellular delivery of a drug to a target cell. The present invention also relates to ligand-drug- conjugates for the intracellular delivery of cytotoxic agents in tumor cells.
