Emilee H. FULCHER;Scott D. SORENSEN;John W. LAMPE;Ward M. PETERSON;Tomas NAVRATIL
发明人:
Tomas NAVRATIL,Ward M. PETERSON,John W. LAMPE,Emilee H. FULCHER,Scott D. SORENSEN
申请号：
US13612511
公开号：
US20130005756A1
申请日:
2012.09.12
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention is directed to methods of preventing or treating diseases or conditions of the lungs associated with excessive cell proliferation, remodeling, inflammation, vasoconstriction, bronchoconstriction, airway hyperreactivity and edema. Particularly, this invention is directed to methods of treating pulmonary diseases such as asthma； chronic obstructive pulmonary disease； respiratory tract illness caused by respiratory syncytial virus； pulmonary arterial hypertension； acute respiratory distress syndrome and ventilator induced lung injury； cystic fibrosis； bronchiectasis； alpha-1-antitrypsin deficiency； rhinitis； rhinosinusitis； primary ciliary dyskinesia； pneumonia； bronchiolitis caused by agents other than respiratory syncytial virus； and interstitial lung disease including lymphangioleiomyomatosis； idiopathic pulmonary fibrosis； obliterative bronchiolitis or bronchiolitis obliterans organizing pneumonia due to lung transplantation or HSCT； nonspecific interstitial pneumonia； cryptogenic organizing pneumonia； acute interstitial pneumonia； respiratory bronchiolitis-associated interstitial lung disease； or pulmonary sarcoidosis. The method comprises administering to a subject an effective amount of a rho kinase inhibitor compound to treat the disease.
