Edward J. Olhava,Richard Chesworth,Roy M. Pollock,Lei Jin
申请号：
US15176052
公开号：
US10112968B2
申请日:
2016.06.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to DOT1L inhibitors and methods of identifying, designing, or optimizing them. The present invention also relates to crystals of DOT1L-inhibitor complexes, the crystal structures thereof, and the use of the crystal structures. Also disclosed are pharmaceutical compositions containing these DOT1L inhibitors and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
