A position sensitive illumination system for a patient includes an illumination source and at least one sensor structured and configured to selectively activate the illumination source in dependence of movement of the patient. Illumination source and/or sensor may be provided to one or more portions of a patient interface, e.g., a mask assembly, to thereby allow automatic activation of the illumination source when the patient moves to a predetermined position. Illumination source provides a directed lighted path for the patient as the patient moves about, e.g., during nocturnal visits to the bathroom, thereby avoiding the awakening of a bed partner.