BIERER, DONALD E.,DENER, JEFFREY M.,TRUONG, THIEN V.
申请号：
US19940234483
公开号：
US5811568(A)
申请日:
1994.04.28
申请国别(地区):
美国
年份:
1998
代理人:
摘要：
This invention pertains to a synthetic process for obtaining a unique phosphocholine derivative which has been isolated from the leaves of the plant Irbachia alata, identified to be 1,22-bis[2-(trimethylammonium)ethylphosphatyl] docosane is disclosed. Also disclosed is a synthetic process for obtaining a novel class of mono- and bis(phosphocholine) derivatives which are useful as antiinfective agents. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus.
