The Children's Hospital Of Philadelphia;The Childrens Hospital Of Philadelphia
发明人:
Hakonarson, Hakon,Kao, Charlly,Cardinale, Christopher,Pandey, Rahul,Li, Yun Rose
申请号：
AU2016313506
公开号：
AU2016313506A1
申请日:
2016.08.19
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present disclosure relates to methods of treating autoimmune conditions in patients who have genetic alterations in the TNFRSF6B gene, which codes for the decoy receptor 3 protein (DcR3), for example that reduce the expression, secretion, or ligand binding activity of DcR3. For example, in some embodiments, the conditions may be treated with molecules that inhibit the activity of DcR3 ligands such as LIGHT, TLl A, and FasL, such as anti -LIGHT, anti-TLl A, and anti -FasL antibodies, or inhibitors of the non-canonical NF-κB pathway.
