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תולדות טריאזול תרשירים רוקחיים המכילים אותם ושימושים בהם
专利权人:
ASTELLAS PHARMA INC.
发明人:
申请号:
IL21031610
公开号:
IL210316A
申请日:
2010.12.28
申请国别(地区):
IL
年份:
2014
代理人:
摘要:
[Problem] A compound, which can be used for preventing or treating diseases, in which 11²-hydroxysteroid dehydrogenase type 1 (11²-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided. [Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with -O- (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11²-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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