A FACTOR INCREASING EFFICIENCY OF A DNA VACCINE AGAINST A VIRUS, A PLASMID DNA FORMULATION, A DNA VACCINE, A METHOD OF OBTAINING A MODIFIED EXPRESSION VECTOR AND USE OF A NUCLEOTIDE SEQUENCE RECOGNISED BY THE NF KAPPA B FACTOR
The invention is related to a factor increasing efficiency of a DNA vaccine aimed against a virus, a plasmid DNA preparation, a DNA vaccine, a method of obtaining a modified 3NFKB expression vector and use of a nucleotide sequence recognised by NFKB. More particularly, the provided solution is related to use of a DNA sequence recognised by the NF kappa B nuclear transcription factor (NFKB,nuclear factor kappa B) in a vaccine in order to ensure effective vaccine plasmid transport into the nucleus and to enhance transcription levels of the introduced gene-coding a selected antigen.
