The present invention is generally directed to compositions and methods for amelioration of diseases and related symptoms in domestic animals. In one aspect, the invention is directed to a method of ameliorating the symptoms of arthritis, brain aging, cataracts, diabetes, dermatitis, FLUTD, glaucoma, low energy levels or obesity in a domestic animal, wherein the method comprises administering a composition to the animal, wherein the composition comprises a Fruit-Based Additive, a Vegetable-Based Additive or a Fruit- and Vegetable-Based Additive.