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Methods and Compositions for Treating or Diagnosing Melanoma
专利权人:
发明人:
Tao Wang,Meenhard Herlyn,Russel E. Kaufman
申请号:
US14407607
公开号:
US20150166646A1
申请日:
2013.03.15
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Methods and compositions are provided for treating melanoma in a mammalian subject by reducing, inhibiting or down-regulating tumor-associated macrophage (TAM) production or activity in the subject. The methods can involve a combination of reducing macrophage production and number while administering an anti-cancer therapy. The treatment can involve the combined blocking or down-regulating of the nucleic acid or protein expression or activity, or the downstream pathway of CCL-2 with the blocking or down-regulating of the nucleic acid or protein expression or activity, or the downstream pathway of a matrix metalloprotease (e.g., MMP9). Another aspect involves blocking the expression or activity of VEGF. Another aspect involves blocking or down-regulating the expression, activity or signaling of the MAPK pathway or the PI3K-AKT-mTOR pathway.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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