Warner C. Greene,Gilad Doitsh,Orlando Zepeda,Nicole Galloway
申请号：
US14846652
公开号：
US09352010B2
申请日:
2015.09.04
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided herein are compositions and methods for the treatment of a patient having an HIV-1 infection and/or AIDS. More specifically this invention provides treatment of an HIV-1 infection and/or AIDS using small molecule compounds, such as inhibitors for the activation and/or activity of caspase-1. Inhibitors for the activation and/or activity of caspase-1 also prevent the cell death of CD4 T-cells in a population of CD4 T-cells comprising HIV-1 infected CD4 T-cells and uninfected CD4 T-cells. In addition, caspase-1 inhibitors inhibit inflammation, and pyroptosis.
