Claudiu Supuran,Shoukat Dedhar,Paul C. McDonald,Fabrizio Carta
申请号:
US13737704
公开号:
US09463171B2
申请日:
2013.01.09
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Therapeutic ureido-sulfonamide compositions having compounds with the formulaR-Q-Ar—SO2NH2 are disclosed, which compounds selectively inhibit CAIX and CAXII, and which are effective to inhibit hypoxic tumor growth, suppress metastases, and impair and deplete cancer stem cells in mammals.