Birgit Bramlage,Hans-Peter Vornlocher,Markus Hossbach,Pamela Tan
申请号：
BRPI0916440
公开号：
BRPI0916440A2
申请日:
2009.07.08
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a TGF-beta receptor type I gene, comprising an antisense strand having a nucleotide sequence which is less than 30 nucleotides in length and which is substantially complementary to at least a part of a TGF-beta receptor type I gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier； methods for treating diseases caused by the expression of a TGF-beta receptor type I gene using said pharmaceutical composition； and methods for inhibiting the expression of a TGF-beta receptor type I gene in a cell.
