The invention relates to the field of food industry, pharmaceutical and medical sciences, with sub-fields of natural and complementary medicine. The present invention relates to the composition of water-soluble natural, synthesis and semi-synthesis cannabinoids or a mixture thereof in the form of nanoparticles. The essence of the invention is in the composition of water-soluble natural, synthesis or semi-synthetic cannabinoids, or a mixture thereof in the form of nanoparticles, where a combination of maltodextrin, polysorbate 80 and arabicum gum is used as a solubilizer, the nanoparticles being prepared by ultrasound.Izum spada na področje prehrambne industrije, farmacevtskih in medicinskih znanosti in ved, s pod-področji naravne in komplementarne medicine. Predloženi izum se nanaša na sestavo vodotopnih naravnih, sinteznih in pol-sinteznih kanabinoidov ali njihove mešanice v obliki nanodelcev. Bistvo izuma je v sestavi vodotopnih naravnih, sinteznih ali polsinteznih kanabinoidov ali njihove mešanice v obliki nanodelcev, kjer je kot solubilizator uporabljena kombinacija maltodekstrina, polisorbata 80 in gumi arabikuma, pri čemer se nanodelci pripravijo z izpostavitvijo ultrazvoku.
