ANA SILVIA SARTORI BARRAVIERA SEABRA FERREIRA,MOACYR RAMOS BIGHETTI
申请号：
BR102017008027
公开号：
BR102017008027A2
申请日:
2017.04.18
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
process for obtaining fibrin sealant, means for applying said fibrin sealant, and process for applying said fibrin sealant, whereby dehydration and grinding of both sealant components (serinoprotease purified from snake venom or the use of the same component from its synthesis in the laboratory by known methods, and the fibrinogen-rich cryoprecipitate extracted from large animals), resulting in the obtainment of two pulverulent components, the properties of which remain unchanged for a long period of time. , dispensing freezing； These two powdered components are either supplied separately within independent, watertight chambers provided in a first applicator means, or are mixed together and impregnated with a support member provided in a second applicator means, or only one of them is impregnated with a support element provided in the same second applicator means, or even just one of them is mixed with a substance which gives it consistency, forming a third applicator means； in the first two cases provision is made for the supply of a diluent liquid, stored separately, either in an independent, watertight chamber provided for in the first applicator means or in a separate, watertight compartment provided for in the second applicator means； In the other two cases, said diluent liquid is mixed with the other powder component, and stored either in the separate, watertight compartment provided for in the second applicator medium or in the usual spray bottle.processo de obtenção de selante de fibrina, meios de aplicação do referido selante de fibrina, e processo de aplicação do referido selante de fibrina, segundo os quais são previstas a desidratação e a trituração de ambos os componentes do selante (a serinoprotease purificada a partir de veneno de serpente ou a utilização do mesmo componente proveniente de sua síntese em laboratório através de métodos conhecidos, e o crioprecipitado rico em fibrinogênio extraído de grandes animais), resultando na obtenção de dois comp
