The present disclosure is directed to reduced calorie infant formulas, and in particular, reduced calorie infant formulas that have at least one nucleotide and/or at least one carotenoid for reducing inflammation-related diseases later in life. Particularly, the reduced calorie infant formulas reduce the risk of obesity later in life.本發明係有關低卡路里嬰兒配方,特別是具有至少一種核苷酸及/或至少一種類胡蘿蔔素之低卡路里嬰兒配方,用於減少後續生命中發炎相關疾病。特別地,該低卡路里嬰兒配方降低後續生命中肥胖之風險。