PATRICK HENRY BEUSKER,RUDY GERARDUS ELISABETH COUMANS,RONALD CHRISTIAAN ELGERSMA,WIRO MICHAEL PETRUS BERNARDUS MENGE,JOHANNES ALBERTUS FREDERIKUS JOOSTEN,FRANCISCUS MARINUS HENDRIKUS GROOT DE,HENRI JO
申请号：
PT16154533
公开号：
PT3056203T
申请日:
2011.04.21
申请国别(地区):
PT
年份:
2018
代理人:
摘要：
This invention relates to novel conjugates of the DNA-alkylating agent CC-1065. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The conjugates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the conjugates of this invention may be used to treat a tumor.
